Zofran

Overview

Consumer Alert: Popular Anti-Nausea Drug Zofran Linked to Birth Defects

Zofran is an anti-nausea drug not FDA-approved for use during pregnancy, but often prescribed "off label" for morning sickness. It is associated with an increased risk of cleft palate and congenital heart defects.1

1 M. Anderka et al. Medications Used to Treat Nausea and Vomiting of Pregnancy and Risk of Selected Birth Defects. Birth Defects Res A Clin Mol Teratol. (Jan. 2012); JT Anderson et al. Ondansetron use in Early Pregnancy and the Risk of Congenital Malformations – A Register Based Nationwide Cohort Study. Pharmacoepidemiology and Drug Safety. (Oct. 2013)

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